The acronym SARMs stands for Selective Androgen Receptor Modulators. A hormone called androgen serves as a ligand (any ion or molecule that binds to a central atom) that attach to the androgen receptors.
It is possible for a certain drug to offer favorable results to a specific tissue if that drug would be able to stimulate or block a particular tissue’s receptor. It can do that while minimizing the unfavorable effects that synthetic or natural steroidal hormones might bring to the other tissues. This is good news for steroid users, especially if pharmaceutical companies will be able to develop such drug for human consumption.
Selective AR (androgen receptor) modulators can also give the same benefits that anabolic androgenic steroids (like testosterone) usually offer including fat reduction and increased muscle mass. SARMs offer the said benefits together with a lesser possibility of producing the unfavorable side effects that typically come with steroids.
There are pharmaceutical companies that are currently studying and investigating the said compound. These companies hope that they will be able to develop something that can bring safe and beneficial effects to humans.
The Reason for Selective Androgen Receptor Modulators’ Existence
Typically, doctors prescribe steroids for patients who need to undergo hormone replacement therapy. Steroid is also prescribed to patients suffering from cancer, osteoporosis, or other diseases that can lead to muscle wasting.
Although testosterone replacement therapy or anabolic steroids can bring great help, it is a known fact that they also give undesirable side effects.
This dilemma has stirred the desire and inspired the scientists to find something that will be able to give the same benefits as the steroids without causing unfavorable side effects. What comes next is nonstop research which eventually created an opportunity for SARMs to be discovered.
The said receptor modulators can make muscle growth possible in the target area and eliminate or reduce unfavorable side effects.
The discovery of selective AR modulators gave a new hope that it will be able to serve as a safer alternative to steroids. But before that, the pharmaceutical companies must be able to make the said receptor safe for human consumption.
A number of pharmaceutical companies are still exploring, evaluating, and testing possible AR modulators because there are several possible receptor modulators out there. Most bodybuilders, athletes, or fitness enthusiasts are interested in MK-2866 (ostarine) and andarine (popularly known as S-4).
Bodybuilders and athletes are also interested in other AR modulators, but the most popular are the mentioned two.
Anabolic steroids or hormone replacement could have been the perfect solution if not for the unwanted side effects. The unfavorable side effects include cholesterol imbalance, acne, hypertension, body hair growth, liver toxicity, and heart enlargement (left ventricular hypertrophy). Some men may also experience baldness, possible simulation of prostate cancer, gynecomastia (man breast), and testosterone production shutdown.
The selective androgen receptor modulators can provide the benefits that the users get from steroids while minimizing the occurrence of the unfavorable side effects of anabolic steroids or hormone replacement. The said selective AR modulators can be taken orally. Steroid users appreciate the idea that they no longer need to go through the inconvenience of taking the shots if a drug that contains selective AR modulators is already available.
Other advantages of selective androgen receptor modulators over steroids or testosterone replacement therapy are: similar benefits of testosterone, no conversion to estrogen and dihydrotestosterone, and absence of harsh liver toxicity which usually comes from methylated compounds.
SARMs can give a lot of benefits and probably even more. For now, it is still considered one of the research chemicals that need to be explored further. Hopefully, pharmaceutical companies will be able to make it safe for human consumption.